Chloe Spade is an in-home nurse sent to the home of protagonists, Lance and Brooke, after the couple was in a car accident that killed a man named Darren Wells, and left Lance with a broken leg. During her time at the home, Chloe develops romantic feelings for Lance, and has even resorted to coming on to him and also trying to kiss him. She is later shown on her laptop looking at photos of Lance and Brooke together, and also looking up information on overdoses on oxycodone, which later happens to Lance.
At the hospital, Lance tells Brooke that Chloe had been making passes at him, which leads Brooke to call the police, believing that Chloe drugged Lance. It is later revealed that Chloe has a dark history; she is a manic depressive on medication. Also, Chloe developed romantic feelings for a married man when she cared for him in Brentwood, and when he didn't reciprocate, she trashed his place. Chloe attempted to visit Lance at the hospital with flowers, but she is stopped by Brooke, which led to a verbal confrontation where Brooke fired Chloe, leading the villainess to accuse Brooke of not appreciating what she had. She later hears the couple's conversation with their lawyer friend, Gwen, while attempting to visit Lance again. After hearing that they plan to take her down, Chloe confronts Gwen in a parking garage and attacks her, leaving her in a coma. Chloe visits the home again, pleading her case and stating that she didn't drug Lance, only for Barbara Stone, who replaced Chloe, to prevent her from entering.
Chloe is later found unconscious at her home by police after she attempted suicide via an overdose of oxycodone. She is at the hospital assumingly cared for by Barb, who later disclosed that she paid her $2,500 to ruin the lives of Lance and Brooke as part of her plan to get revenge on the couple for Darren Wells' death; Barb's fiancé. Chloe is drugged and placed in the trunk of Barb's car along with her boyfriend (who Barb was implied to have killed earlier), but she later escapes and breaks into the couple's home, where she finds Barb attempting to kill Lance. After ordering Barb to back away from Lance while pointing a gun at her, Chloe then ends up further drugged by Barb after she promised to double her pay. Barb was ultimately subdued and, lthough Chloe's fate is never revealed, Brooke decides to "get her some help" after Lance inquires about what they should do with her, most likely indicating that Chloe was institutionalized offscreen.