Isabella is Charlie's Satan-worshipping girlfriend in the episode, and she is shown plaguing Alan with her practicing dark magic. She takes Alan's hair from his brush and threatens to place a curse on him. Alan mocks Isabella, only to end up nicking himself shaving--all the while, Isabella is heard laughing evilly. Regarding Charlie, Isabella introduced him to a coven of women as part of a plan to bring a Satanic spawn into the world. Just before the ritual is set to begin, Evelyn appears in her Halloween costume (the Wicked Witch of the West) and makes a veiled warning to Isabella, prompting the villainess to back off.
Isabella resurfaced as a haunting hallucination in Season Seven's "Gumby With a Pokey," and appeared as one of the many ex-girlfriends who attended Charlie's funeral in the anticipated Season Nine opener, "Nice to Meet You, Walden Schmidt."
- Jodi Lyn O'Keefe appeared as bully Taylor Vaughn in the 1999 teen movie She's All That.
- Jodi Lyn O'Keefe appeared as Debbie Strand in the 2000 movie, Devil in the Flesh 2, which is also known as Teacher's Pet.
- Jodi Lyn O'Keefe appeared as the villainess Layla Simmons in the 2004 film, Vampires: Out For Blood.
- Jodi Lyn O'Keefe appeared as the Spider Demon in the 2004 episode "Spider Demon" for the TV series Charmed,
- Jodi Lyn O'Keefe appeared as Gretchen Morgan from 2007-2009 in the TV series Prison Break.
- Jodi Lyn O'Keefe appeared as Lisa aka Mandy in the 2012 episode "A Cinderella Story" from the TV series The Finder.