- Sally Warren and Peggy Bannon (Highway Patrol)
- Sally and Kowalski (George Of The Jungle 2)
- Salome (Savage Sword of Conan)
- Saloon Girls (The Big Valley)
- Samantha (Fear Itself)
- Samantha (Lois & Clark)
- Samantha (Republic of Doyle)
- Samantha (Stranger in the House)
- Samantha (The Hospital 2)
- Samantha (The Silicon Assassin Project)
- Samantha Berry (Fatherly Obsession)
- Samantha Brown (The Wrong Daughter)
- Samantha Dolan (Sue Thomas: F.B.Eye)
- Samantha Drake (Smallville)
- Samantha Felton (Johnny Yuma)
- Samantha Gray (Schizo)
- Samantha Kaye (Republic of Doyle)
- Samantha Lee (Dante)
- Samantha Lockwood (Awake)
- Samantha Northcliff (Castle)
- Samantha Orland (Backstrom)
- Samantha Ruland (Scandal)
- Samantha Stevens (Love and Curses)
- Samantha Vanaver (Batman vs. Robin)
- Samantha Weaver (Law & Order)
- Samantha Wilson (CSI)
- Samarra (Bez Bebek)
- Samm Jang (Dungeon Fighter Online)
- Sammy Feldon (Zombie at 17)
- Sanae Asou (Kindaichi 37 Years Old Case Files)
- Sandi Clark (Held Hostage)
- Sandra (Cobra)
- Sandra (Denya Okhra)
- Sandra (I Didn't Kill My Sister)
- Sandra Babcock (Crossing Jordan)
- Sandra Boatwright (The Mentalist)
- Sandra Bradshaw (Midsomer Murders)
- Sandra Chandler (CSI: NY)
- Sandra Hurst (The Champions)
- Sandra Lustenberg (The Adventures of Superseven)
- Sandra Martin (Sue Thomas: F.B.Eye)
- Sandra Mornay (Abbott and Costello Meet Frankenstein)
- Sandra Pence (CSI)
- Sandra Rusk (Knight Rider)
- Sandra Tremayne (Jennifer)
- Sandra Walkey (CSI)
- Sandra Wolfe (The Second Arrival)
- Sandy (A Deadly View)
- Sandy (Big Time Rush)
- Sandy Langford (Rosewood)
- Sandy Sneakers (A Pup Named Scooby Doo)
- Sandy Walsh (Crossing Jordan)
- Santana Garrett (TNA)
- Santrina (Sheigala: Vampire Business Women)
- Santánico Pandemonium (From Dusk Till Dawn)
- Sappho Living (EP Risate)
- Sara (Femme Fatales)
- Sara (Lady in Red)
- Sara (Santo vs Doctor Death)
- Sara Brown (Hawaii Five O)
- Sara Burns (Lethal Weapon)
- Sara Campbell (Unnatural History)
- Sara Del Rey (SHIMMER)
- Sara Dexter (Pacific Blue)
- Sara Gunderson (Holidays)
- Sara Morgan Bratchett (Second to Die)
- Sara Parkson (Body of Proof)
- Sara Penney (The Avengers)
- Sara Strand (NCIS: New Orleans)
- Sarabeth (Goosebumps)
- Sarafine Duchannes (Beautiful Creatures)
- Sarah & Nikki (Longmire)
- Sarah (Kamen Rider Den-O & Kiva: Climax Deka)
- Sarah (Pressure and Time)
- Sarah Barns (NCIS: New Orleans)
- Sarah Bell (Warehouse 13)
- Sarah Bellum (Where On Earth Is Carmen Sandiego?)
- Sarah Bennett (Criminal Case)
- Sarah Blackwell (Republic of Doyle)
- Sarah Davis (Picture Perfect Mysteries)
- Sarah Flint (Law & Order: SVU)
- Sarah Green (Unforgettable)
- Sarah Logan (WWE)
- Sarah Longson (Monk)
- Sarah Lowell (NCIS)
- Sarah Lynch (Bull)
- Sarah Madeley (New Tricks)
- Sarah Maitland (New Tricks)
- Sarah McLeish (Murder, She Wrote)
- Sarah Miller (Watch Your Back)
- Sarah Muller (Motive)
- Sarah Nade (Where In The World Is Carmen Sandiego?)
- Sarah Newlin (True Blood)
- Sarah Ravencroft (Scooby-Doo and the Witch's Ghost)
- Sarah Sanderson (Hocus Pocus)
- Sarah Sinclair (McBride: Dogged)
- Sarah Soble (Crossing Jordan)
- Sarah Stockwood (Vexed)
- Sarah Webb (Tru Calling)
- Sarah Winslow (New Tricks)
- Saralynn O'Brien (Fear Street)
- Saranoia (Yin Yang Yo!)
- Sari Clayton (Diary Loves)
- Sarina Akutsu (Case Closed)
- Sarita (TNA)
- Sarita (The Silencers)
- Sasha/The Leper (Andromeda)
- Sasha (Pair of Kings)
- Sasha (Ready to Rumble)
- Sasha (Red Serpent)
- Sasha Banacek (The Adventures of Superseven)
- Sasha Banks (WWE)
- Sasha Boyd (CSI: Cyber)
- Sasha Harrington (Christmas Crime Story)
- Sasha Johnson (Scary Endings)
- Sassy Fanny (American Muscle)
- Satan Girl (Satan Girl)
- Satana (The Astro-Zombies)
- Satanic Vampires (Moana)
- Satrina (Xena: Warrior Princess)
- Saturn (Mighty Man And Yukk)
- Satō Matsuzaka (Happy Sugar Life)
- Savannah Bellows (Diagnosis Murder)
- Savannah Blake (Criminal Case)
- Savannah Evans (QOC)
- Saya (Namco X Capcom)
- Saya (Naruto)
- Saya Kitami (Case Closed)
- Sayara Yamanobe (Mnemosyne)
- Scam Woman (Seinfeld)
- Scandal Savage (Suicide Squad: Hell to Pay)
- Scarlet (Final Fantasy VII)
- Scarlet Overkill (Minions)
- Scarlett (Scarlett)
- Scarlett (Secrets in Suburbia)
- Scarlett (Total Drama)
- Scarlett Marquesa (The Mentalist)
- Scarlett Price (Castle)
- Scarlett Reynolds (American Dad!)
- Scarlotta (Timeless Tales)
- Scary Mary & Connie the Crusher (Black Scorpion)
- Scheming Wife (Toyota)
- Schneka (They Came From Outer Space)
- Schoolteacher (No Pressure)
- Scientist (The Basil Brush Show)
- Scorned Brunette (American Horror Story: Apocalypse)
- Scorned She-Wolf (Scorcher)
- Scorpia (She-Ra: Princess of Power)
- Scorpina (Mighty Morphin Power Rangers)
- Scorpion (Cobra II)
- Scorpion (Shin Cutie Honey)
- Scorpion Boss (Secret of Mana)
- Screamer (Silent Hill: Downpour)
- Screech and Shreik (Black Scorpion)
- Scuba Girl (James Bond)
- Scylla (Hugo)
- Se-Young (The Wicked)
- Sea Woman (Conan The Barbarian)
- Second Sister (Star Wars)
- Secretarial Assassins (The Avengers)
- Secretary (The Crow: Salvation)
- Sedusa (The Powerpuff Girls)
- Sela (Star Trek: The Next Generation)
- Selen Garcia (Beyblade)
- Selena (Forbidden Worlds)
- Selena (Lure of the Temptress)
- Selena (Supergirl)
- Selena (Supergirl TV Series)
- Selena (Wizards of the Demon Sword)
- Selena Izard (The House With A Clock In Its Walls)
- Selena Palmer (Il Marchese)
- Selena Perrini (Collateral Damage)
- Selena Rigas (Castle)
- Selene (Fortune Summoners)
- Selene (Grandia II)
- Selene (Marvel Comics)
- Selene Harverston (Christie's Revenge)
- Selima (Triumph of the Ten Gladiators)
- Selina (Burn Notice)
- Selina (The Sanctuary)
- Selina Matias (Mula Sa Puso)
- Selma (The Last House)
- Semira (Underworld: Blood Wars)
- Semmerling (Riding Bean)
- Senora Piranda (Hart to Hart)
- Sensational Sherri (WWE)
- September Jones (Death Race 2)
- Sera (Hercules: The Legendary Journeys)
- Sera Morrison (Criminal Minds)
- Serena (Chuck)
- Serena (My Babysitter's a Vampire)
- Serena (Snake Eyes)
- Serena (WWE)
- Serena Johnson (Criminal Case)
- Serena Wilson (PSI Factor)
- Sergeant Gruber (The Professional)
- Sergeant Reznik (The 5th Wave)
- Serial Black Widow (The Golden Girls)
- Serleena (Men In Black II)
- Serpens Rex (World Destruction/Sands of Destruction)
- Serra Venta (Strange Planets)
- Serving Girl (Flash Gordon)
- Seryu Ubiquitous (Akame Ga Kill)
- Seteki (Strange Brigade)
- Sevanna (The Wheel of Time)
- Seventh Sister (Star Wars Rebels)
- Sexy Bodyguards (The Last Mercenary)
- Sexy Leather Clad Woman (Transporter: The Series)
- Shaant's Girlfriend (The Curse of Curves)
- Shabla (Storie Blu Special)
- Shadow Queen (Paper Mario: The Thousand-Year Door)
- Shadow Weaver (She-Ra: Princess of Power)
- Shady Lady (Blue Beetle)
- Shahdee (Prince of Persia: Warriors Within)
- Shanaya Peota (Criminal Case)
- Shanda (Diagnosis Murder)
- Shandray (Solarbabies)
- Shania Costa (Blue Bloods)
- Shaniqua (WWE)
- Shannon (God Hand)
- Shannon Bell (Smallville)
- Shannon Daring (Thunder in Paradise)
- Shannon Dennings (Crimes of Passion)
- Shannon Lucas (Scooby Doo! Moon Monster Madness)
- Shannon Turner (CSI)
- Sharon (Legam)
- Sharon Baskin (Murder, She Wrote)
- Sharon Doorson (Killer)
- Sharon Ellison (Diagnosis Murder)
- Sharon Lutz (Mr. Right)
- Sharon Marshall (Proven Innocent)
- Sharon Miller (Pretty Little Dead Girl)
- Sharon Noles (Fear Street)
- Sharon Perleen (Matlock)
- Sharon Quinzel (Harley Quinn)
- Sharon Whit (Mr. Belvedere)
- Sharon Wilson (Adam-12)
- Sharon Wimple (Terror Blu)
- Sharona Skye (Sonny With A Chance)
- Shauna Teague (Diagnosis Murder)
- Shawna Knox (Criminal Case)
- Shayla (Vampire in Vegas)
- Shayna Baszler (WWE)
- She-Demon (Hercules: The Legendary Journeys)
- She-Devil Of The Coliseum (Metamorphic Force)
- She-Vampires (The Astonishing Adventures of Mr. Weems and the She Vampires)
- Shea Lammet (CSI)
- Shea Williamson (CSI: Miami)
- Sheala de Tancarville (The Witcher 2: Assassins of Kings)
- Sheba (Top-Notch Comics)
- Sheetar (Blood Diner)
- Shego (Kim Possible 2019)
- Sheila (Space Cobra)
- Sheila (Storie Blu Special)
- Sheila Altoonian (Scooby Doo! Mystery Incorporated)
- Sheila Black (Criminal Case)
- Sheila Cornhole and the Mitchell & Webb Glam Fam Sales Force (American Dad!)
- Sheila Forbes (The New Mike Hammer)
- Sheila Ganz (Crossing Lines)
- Sheila Grant (Witness Unprotected)
- Sheila Latham (CSI)
- Sheila Lord (The Beyond)
- Sheila Martini (Buffy The Vampire Slayer)
- Sheila Nolan (Highway Patrol)
- Sheila Parker (Death in Paradise)
- Sheila Porter (Law & Order: SVU)
- Sheila Ross (Common Law Cabin)
- Sheila Vestal (Lucifer)
- Shelby Coulson (Perception)
- Shelby Mercer (Homecoming)
- Shelley Meyers (Scandal)
- Shelley Waggoner (Unnatural History)
- Shelly Dulard (Criminal Case)
- Shelly Junglelove (Totally Spies)
- Shepherd (Blindspot)
- Sherese (Buck Rogers in the 25th Century)
- Shermans (God Mazinger)
- Sherra (Slayers)
- Sherry Gibbs (Private Eyes)
- Sherry Landis (Sexual Roulette)
- Shimura (Devilish Girlfriend)
- Shino Tachibana (Case Closed)
- Shinseiki (Skyland)
- Shiori Tsuzuki (Witchblade)
- Shirley (Batman)
- Shirley (Get Smart)
- Shirley (Totally Spies)
- Shirley Finnerty (Night of the Demons 2)
- Shiva (Batman: Arkham Origins)
- Shizuka (The Superb Captain in the City)
- Shizuka Of The Wind (GoGo Sentai Boukenger)
- Shoko Hisazu (Case Closed)
- Shotgun Terrorist (Target: Terror)
- Shpilka (They Came From Outer Space)
- Shreeka (Teenage Mutant Ninja Turtles)
- Shriek (Venom: Let There Be Carnage)
- Shtarka (They Came From Outer Space)
- Shurikai (Ninjak)
- Siann (Mortal Kombat: Conquest)
- Sibella Stone (Murder, She Wrote)
- Sic (The Adventures of Superseven)
- Sick Woman (CSI: Cyber)
- Siegfried's Sister (Get Smart)
- Sienna (TNA)
- Sienne Miller (Prom Ride)
- Sil (Species)
- Silica (Jem)
- Silken Floss (The Spirit)
- Silkie (Amos Burke: Secret Agent)
- Silvana (Electra One)
- Silver Banshee (Suicide Squad: Hell to Pay)
- Silver Sable (The Spectacular Spider-Man)
- Simone (Lois and Clark: The New Adventures of Superman)
- Simone (SWAT: Under Siege)
- Simone Charcot (Smallville)
- Simone Clouseau (The Pink Panther)
- Simone Colgate (Private Eyes)
- Simone De Marchi (The Perfect Host)
- Simone Hollingsworth (Midsomer Murders)
- Simone Matthews (The Perfect Girlfriend)
- Simone Perry (Fear Street)
- Simonetta (The Most Wonderful Evening of My Life)
- Sin and Dementiia (BloodStorm)
- Sinclair John (The Foreign Exchange Student)
- Sindy (Polar)
- Sinister Sphinx (Blue Beetle)
- Siobhan McDonagh (Republic of Doyle)
- Siobhan Miller (Law & Order: SVU)
- Siobhan Smythe (Supergirl)
- Siren (Charmed)
- Siren (Final Fantasy V)
- Siren (Triage X)
- Sirenas (Groo The Wanderer)
- Sirens (Greek Mythology)
- Sirens of Space-Time (Legends of Tomorrow)
- Siriadne (Shard of Spring)
- Sirius Scientist (Terror Blu)
- Siska (Superbabies: Baby Geniuses 2)
- Sister Anna Lee (Guns For Dollars/They Call Me Hallelujah)
- Sister Anne (Death in Paradise)
- Sister Jill (Cutey Honey)
- Sister Nora (Sometimes the Good Kill)
- Sister Of Black Dragon (Angel Warriors)
- Sister Regina (Diagnosis Murder)
- Sister Sisto (Solar Opposites)
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