Natalie convinced Ian to reach out to Haley Tyler, Ian's illegitimate daughter, who has the same rare blood type as Ian. Natalie, a retired doctor, gave Haley an injection and told her that it was for medical research. In actuality, Natalie was poisoning Haley's blood so it would also poison and eventually kill Ian when it was transfused to his body. In an earlier interrogation, Natalie stated that she gave up 20% of the inheritance to Haley, but as revealed later on, she did so mainly to maintain Haley's trust, as well as keeping Natalie's villainous motives a secret from Haley.
Later on, Natalie turned heel and killed Haley in her apartment, stabbing her to death with a knife. The villainess committed the murder to prevent Haley from finding out the truth about her sudden illness, and as part of her plan, the evil Natalie attempted to make the murder look like a botched robbery. However, once Haley fell off the balcony, Natalie fled the scene. After her role was revealed, Natalie was arrested (off-screen) for killing Haley and Ian.
- Margaret Colin also played villainess Ms. Krug on Law & Order: SVU.