A Persian ruler, she has women abducted and sells them as slaves. One of these is the beautiful Nofret (Federica Ranchi). When her husband, Pharaoh Armiteo I (Carib Tamberlani), finds out what she has been doing behind his back and reprimands her for her behavior, she has him secretly killed. She then controls the new successor, Pharaoh Kenamun (Angelo Zanolli) by using an evil necklace. She drugs him with a substance that loses his will-power.
Maciste (Mark Forest), the son of Samson, unites people to rise up against her tyranny. Smedes uses a sultry dance to attempt to seduce Maciste.
Once surrounded, she has the last laugh (literally), boasting that they will never execute her, and then throws herself to the crocodile pit in her secret chamber along the Nile River to avoid justice.
The name Samson appears in the title but this has no relationship to the biblical Samson.