Susan was one of the six women who gave birth to baby girls on June 6, 1994, beginning a prophecy that stated that one of them would become the "Devil's Hand," an emissary of Satan, on her 18th birthday. One of the girls, Rose, is killed by her mother after birth, leaving Susan's daughter, Mary, as one of the five remaining girls. Susan noticed that Mary was having potentially deadly seizures, and prayed to God for her to get well, only for her to continue to suffer. As a result, Susan renounced God and ended up ex-communicated from the community they resided in.
Nearly 18 years to the day later, Susan returned to the community under a hidden cloak and killed each of the four other girls, as well as Mary's evil stepmother, Rebekah. Mary had believed her mother to be deceased until her father, Jacob Brown, told her the truth. Afterwards, Susan reunited with Mary, who was driven there by Trevor, and Susan gave the impression that Elder Beacon, a religious fanatic, was the one killing the girls. Susan sees Mary again minutes before midnight on her 18th birthday and confesses everything; stating that she killed the other girls to change the demonic prophecy and making sure that Mary becomes the Devil's Hand and lives at full strength. After her confession, the evil Susan watched as Mary kissed Trevor and later killed him by snapping his neck, fulfilling the Satanic prophecy and making Mary the Devil's Hand.
- Stacy Edwards also appeared on Lie to Me as villainous psychiatrist Christina Knowlton, and appeared on The Mentalist as murderess Concetta Wale.
- Stacy Edwards also portrayed redeemed child molestor Meredith Rice in an episode of Law & Order: SVU.
- "You were weak, Mary. You are sickly, plagued by your fits. The prophey said only one of you six girls would live, only the strongest would survive. I prayed for God to heal you. He turned His back on me. (Mary: "What did you do?") I cursed His name, renounced Him. And then I was offered the chance to keep you alive." (Susan Brown revealing her motive for her murderous actions)
- "I made sure you were the one. I've been in service to you. You are not going to need my help any longer. You will finally be free, your power complete." (Susan expressing her maniacal pride over her villainous actions)